EVALUATION OF THE PREVENTIVE EFFECTS OF CIRRHOSIS OF AN XOA PLANT EXTRACT (Helicteres hirsuta Lour) IN EXPERIMENTAL ANIMALS


Các tác giả

  • Thang Hoang Đac Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Phan Nguyen Thong Military Hospital 175
  • Hien Truong Thi Thu Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Anh Hoang Le Tuan Center for Research and Technology Transfer, Vietnam Academy of Science and Technology
  • Tuan Hoang Anh Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Tung Tran Van Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Binh Nguyen Thanh Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Toan Le Quoc Center for Training and Research in Toxicology and Radiology, Military Medical Academy
DOI: https://doi.org/10.59354/ydth175.2024.269

Từ khóa:

Cirrhosis, CCl4, Helicteres hirsuta Lour, white rats

Tóm tắt

Objective: To evaluate the prophylactic effects of cirrhosis of Helicteres hirsuta Lour (HHW) in experimental animals.

Subjects and methods: White rats were divided into four groups, each with 10 rats. Group 1: the control group drank distilled water at 10 ml/kg body weight per day. Groups 2, 3, and 4 were subcutaneously injected with CCl4 dissolved in olive oil twice a week for 12 weeks to induce cirrhosis. Group 2: (CCl4 group) drank distilled water at 10 ml/kg body weight per day. Group 3: (Silymarin group) drank silymarin at a dose of 0.2 g/kg body weight per day. Group 4: (HHW group) drank HHW at a dose of 1.3 g/kg body weight per day.

Results: The activities of AST, ALT, and GGT in the Silymarin and HHW groups were significantly lower than in the CCl4 group, with p < 0.001 and p < 0.05, respectively. Histopathological images showed that 7/10 rats in the CCl4 group developed F4 stage cirrhosis, while in the Silymarin and HHW groups, only 2/10 rats, the majority of rats had liver fibrosis at stages F2 and F3.

Conclusion: HHW at a dose of 1.3 g/kg body weight had the effect of hepatoprotective against liver fibrosis caused by CCl4 in white rats.

Tài liệu tham khảo

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Zhan Y Y, Wang J H, Tian X, et al (2016). “Protective effects of seed melon extract on CCl(4)-induced hepatic fibrosis in mice”. J Ethnopharmacol, 193 531-537.

Fortea J I, Fernández-Mena C, Puerto M, et al (2018). “Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats – Improving Yield and Reproducibility”. Scientific Reports, 8 (1), 1-10.

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Pham H N T, Vuong Q V, Bowyer M C, et al (2017). “Phytochemical profiles and antioxidant capacity of the crude extracts, aqueous- and saponin-enriched butanol fractions of Helicteres hirsuta Lour. leaves and stems”. Chemical Papers, 71 (11), 2233-2242.

Wei X l, Fang R t, Yang Y h, et al (2015). “Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats”. BMC Complementary and Alternative Medicine, 15 (2015), 1-9.

Tải xuống

Số lượt xem: 122
Tải xuống: 83

Đã xuất bản

30-06-2024

Cách trích dẫn

Hoang Đac , T., Nguyen Thong , P., Truong Thi Thu , H., Hoang Le Tuan , A., Hoang Anh , T., Tran Van , T., Nguyen Thanh , B., & Le Quoc , T. (2024). EVALUATION OF THE PREVENTIVE EFFECTS OF CIRRHOSIS OF AN XOA PLANT EXTRACT (Helicteres hirsuta Lour) IN EXPERIMENTAL ANIMALS. Tạp Chí Y Dược Thực hành 175, (38), 10. https://doi.org/10.59354/ydth175.2024.269

Số

Số 38 (2024): JOURNAL OF 175 PRACTICAL MEDICINE AND PHARMACY

Chuyên mục

CÔNG TRÌNH NGHIÊN CỨU KHOA HỌC