EVALUATION OF THE PREVENTIVE EFFECTS OF CIRRHOSIS OF AN XOA PLANT EXTRACT (Helicteres hirsuta Lour) IN EXPERIMENTAL ANIMALS


Các tác giả

  • Thang Hoang Đac Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Phan Nguyen Thong Military Hospital 175
  • Hien Truong Thi Thu Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Anh Hoang Le Tuan Center for Research and Technology Transfer, Vietnam Academy of Science and Technology
  • Tuan Hoang Anh Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Tung Tran Van Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Binh Nguyen Thanh Center for Training and Research in Toxicology and Radiology, Military Medical Academy
  • Toan Le Quoc Center for Training and Research in Toxicology and Radiology, Military Medical Academy
DOI: https://doi.org/10.59354/ydth175.2024.269

Từ khóa:

Cirrhosis, CCl4, Helicteres hirsuta Lour, white rats

Tóm tắt

Objective: To evaluate the prophylactic effects of cirrhosis of Helicteres hirsuta Lour (HHW) in experimental animals.

Subjects and methods: White rats were divided into four groups, each with 10 rats. Group 1: the control group drank distilled water at 10 ml/kg body weight per day. Groups 2, 3, and 4 were subcutaneously injected with CCl4 dissolved in olive oil twice a week for 12 weeks to induce cirrhosis. Group 2: (CCl4 group) drank distilled water at 10 ml/kg body weight per day. Group 3: (Silymarin group) drank silymarin at a dose of 0.2 g/kg body weight per day. Group 4: (HHW group) drank HHW at a dose of 1.3 g/kg body weight per day.

Results: The activities of AST, ALT, and GGT in the Silymarin and HHW groups were significantly lower than in the CCl4 group, with p < 0.001 and p < 0.05, respectively. Histopathological images showed that 7/10 rats in the CCl4 group developed F4 stage cirrhosis, while in the Silymarin and HHW groups, only 2/10 rats, the majority of rats had liver fibrosis at stages F2 and F3.

Conclusion: HHW at a dose of 1.3 g/kg body weight had the effect of hepatoprotective against liver fibrosis caused by CCl4 in white rats.

Tài liệu tham khảo

Vo Van Chi (1997). Vietnamese Medicinal Plants Dictionary, Volume 2, Medical Publishing House.

Vargas-Mendoza N, Madrigal-Santillán E, Morales-González A, et al (2014). “Hepatoprotective effect of silymarin”. World journal of hepatology, 6 (3), 144-149.

Fernandes D., de Assis E., Souza M., et al. (2020). Helicteres L. Species (Malvaceae sensu lato) as source of new drugs: a review. Química Nova, 43 (6), 787-803.

Zhan Y Y, Wang J H, Tian X, et al (2016). “Protective effects of seed melon extract on CCl(4)-induced hepatic fibrosis in mice”. J Ethnopharmacol, 193 531-537.

Fortea J I, Fernández-Mena C, Puerto M, et al (2018). “Comparison of Two Protocols of Carbon Tetrachloride-Induced Cirrhosis in Rats – Improving Yield and Reproducibility”. Scientific Reports, 8 (1), 1-10.

Gao J, Qin X J, Jiang H, et al (2017). “Detecting serum and urine metabolic profile changes of CCl4-liver fibrosis in rats at 12 weeks based on gas chromatography-mass spectrometry”. Experimental and Therapeutic Medicine, 14 (2), 1496-1504.

Huang Q, Li Y, Zhang S, et al (2012). “Effect and mechanism of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) on hepatic fibrosis induced by carbon tetrachloride in rats”. J Ethnopharmacol, 143 (3), 889-895.

Pham H N T, Vuong Q V, Bowyer M C, et al (2017). “Phytochemical profiles and antioxidant capacity of the crude extracts, aqueous- and saponin-enriched butanol fractions of Helicteres hirsuta Lour. leaves and stems”. Chemical Papers, 71 (11), 2233-2242.

Wei X l, Fang R t, Yang Y h, et al (2015). “Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats”. BMC Complementary and Alternative Medicine, 15 (2015), 1-9.

Tải xuống

Số lượt xem: 224
Tải xuống: 117

Đã xuất bản

30-06-2024

Cách trích dẫn

Hoang Đac , T., Nguyen Thong , P., Truong Thi Thu , H., Hoang Le Tuan , A., Hoang Anh , T., Tran Van , T., Nguyen Thanh , B., & Le Quoc , T. (2024). EVALUATION OF THE PREVENTIVE EFFECTS OF CIRRHOSIS OF AN XOA PLANT EXTRACT (Helicteres hirsuta Lour) IN EXPERIMENTAL ANIMALS. Tạp Chí Y Dược Thực hành 175, (38), 10. https://doi.org/10.59354/ydth175.2024.269

Số

Số 38 (2024): JOURNAL OF 175 PRACTICAL MEDICINE AND PHARMACY

Chuyên mục

CÔNG TRÌNH NGHIÊN CỨU KHOA HỌC