SO SÁNH ĐẶC ĐIỂM CYCLE THRESHOLD-POLYMERASE CHAIN REACTION VÀ KẾT QUẢ ĐIỀU TRỊ GIỮA NGƯỜI BỆNH COVID-19 THỂ NHẸ CÓ VÀ KHÔNG TRIỆU CHỨNG

Trung Võ Nguyên; Tùng Lê Việt; Tuấn Hà Mạnh; Nguyên Trần Ngọc; Thọ Nguyễn Văn; Vinh Nguyễn Quốc

doi:10.59354/ydth175.2023.217

Keywords:

COVID-19, SARS-CoV-2, CT-PCR

Abstract

Purpose: Compare the characteristics of cycle threshold-polymerase chain reaction and treatment outcomes between patients with mild and asymptomatic COVID-19 disease, and find out the factors affecting the results of cycle threshold-polymerase chain reaction and treatment outcomes in both groups.

Methods: Retrospective cohort study of mild and asymptomatic SARS-CoV2 positive cases at concentrated isolation wards in District 10, Ho Chi Minh City from August 16, 2021 to November 6, 2021.

Results: 34.4% of population had symptoms, of which common symptoms were dry cough (20.1%), nasal congestion (13.5%), loss of smell (10.1%), sore throat (8%), and taste loss (7.3%). There was no difference in cycle threshold-polymerase chain reaction at diagnosis of SARS-COV2 infection and at day 7 after follow-up and treatment between symptomatic and asymptomatic groups. The risk-free rate (negative cycle threshold-polymerase chain reaction or ≥35) on day 7 accounted for nearly 50% in both groups. Vaccination reduces the proportion of people with symptomatic COVID-19 and hospital referrals, while comorbidities increased hospitalization and death rates. The symptomatic group had a higher mortality rate than the asymptomatic group.

Conclusions: There was no difference in the cycle threshold-polymerase chain reaction at the time of admission and at day 7 after follow-up, treatment between the symptomatic and asymptomatic groups. The symptomatic group had a higher mortality rate than the asymptomatic group. Vaccination has been shown to reduce the proportion of people with symptomatic COVID-19, while also reducing hospitalizations. Meanwhile, having an underlying disease increased the rate of hospitalization and death.

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