CASE REPORT OF SUCCESSFUL TREATMENT OF ACUTE SUPERWARFARIN RODENTICIDES POISONING IN DEPARTMENT OF OCCUPATIONAL DISEASES, MILITARY HOSPITAL 175


Authors

  • Quỳnh Vũ Thị Trúc Bệnh viện Quân y 175
  • Thiện Cao Đức Bệnh viện Quân y 175
  • Quang Bùi Vinh Bệnh viện Quân y 175
DOI: https://doi.org/10.59354/ydth175.2023.234

Keywords:

superwarfarin poisoning

Abstract

In recent years, the Department of Occupational Diseases, Military Hospital 175 has treated many emergency cases of patients with new generation rat poison poisoning. The old-generation rat poisons which existed 10-20 years ago causing convulsions, coma, and cardiac arrhythmias. Therefore, they have been banned and rarely re-appeared. Followed by the very popular superwarfarin rodenticides poisoning.

We report a case of a 53 years old man who drank 2 ampoules of supperwarfarin and referred to Military Hospital 175 after 4 weeks. The patient was admitted to the hospital with bleeding accompanied by severe coagulopathy, he was actively treated with fresh frozen plasma and blood transfusion, vitamin K1, hemostasis drug. After 7 days, the patient’s health was improved.

References

Bộ Y Tế (2015), Hướng dẫn chẩn đoán và xử trí ngộ độc, Hà Nội, 74- 79.

Lo VM, Ching CK, Chan AY, Mak TW (2008). Bromadiolone toxicokinetics: diagnosis and treatment implications. Clin Toxicol (Phila); 46:703– 10.

Spahr JE, Maul JS, Rodgers GM (2007). Superwarfarin poisoning: a report of two cases and review of the literature. Am J Hematol; 82:656–60.

Bruno GR, Howland MA, McMeeking A, Hoffman RS (2000). Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing. Ann Emerg Med; 36:262–7.

King N, Tran M-H (2015). Long-Acting Anticoagulant Rodenticide (Superwarfarin) Poisoning: A Review of Its Historical Development, Epidemiology, and Clinical Management. Transfus Med Rev; 29:250–8.

Wu Y-F, Chang C-S, Chung C-Y, Lin H-Y, Wang C-C, Shen M-C (2009). Superwarfarin intoxication: hematuria is a major clinical manifestation. Int J Hematol; 90:170–3.

h t t p s : / / m o h . g o v . v n / h o m e ? p _ p _ i d = 1 0 1 & p _ p _ lifecycle=0&p_p_ state=maximized&p_p_ m o d e = v i e w & _ 1 0 1 _ s t r u t s _ action=%2Fasset_publisher%2Fview_ content&_101_type=content&_101_ urlTitle=canh-bao-ngo-oc-thuoc-diet-chuot-the-he-moi

Vandenbroucke V, Bousquet- Melou A, De Backer P, Croubels S (2008). Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. J Vet Pharmacol Ther; 31:437–45.

Kelkar AH, Smith NA, Martial A, Moole H, Tarantino MD, Roberts JC (2018). An outbreak of synthetic cannabinoid–associated coagulopathy in Illinois. N Engl J Med; 379:1216–23.

aChua JD, Friedenberg WR. Superwarfarin poisoning (1998). Arch Intern Med; 158:1929–32.

David John C, Sebastian F, Krutica D (2014). Superwarfarin poisoning and its management, 74-80.

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Published

01-05-2024

How to Cite

Vũ Thị Trúc , Q., Cao Đức , T., & Bùi Vinh , Q. (2024). CASE REPORT OF SUCCESSFUL TREATMENT OF ACUTE SUPERWARFARIN RODENTICIDES POISONING IN DEPARTMENT OF OCCUPATIONAL DISEASES, MILITARY HOSPITAL 175. Journal of 175 Practical Medicine and Pharmacy, (36), 5. https://doi.org/10.59354/ydth175.2023.234