SUY GIẢM TRÍ NHỚ Ở BỆNH NHÂN ĐỘNG KINH ĐA TRỊ LIỆU

Văn Tuấn Lê; Thụy Minh An Lê; Thị Thùy Trang Nguyễn

doi:10.59354/ydth175.2022.28

Keywords:

epilepsy, memory disorder, polytherapy

Abstract

Background: Epilepsy is a common neurological disease. Impaired memory function contributes to increasing the severity of epilepsy, affecting the patient’s quality of life. In epileptic patients with poly-therapy, many factors affect memory function.

Objective: This study aimed to identify the prevalences and features of memory disorders, and clinical factors effected memory disorders in people with epilepsy with polytherapy treatment

Methods: The case series study was conducted from December 2020 to June 2021, included forty-five patients with epilepsy were treatment with two or more AEDs in neurology department. Patients, ≥18 years old, treated in more than 3 months, no recent seizures, were included in this study. Eligible participants were clinically interviewed information, assessed memory by immediate recall, delayed recall, delayed recognition digit span forward, digit span backward.

Results: Forty-five participants (24 male and 21 female) were recruited. The mean age (±SD) was 37.7±13.8 years. In this study, 33.3% participants was identified as memory disorders; and 46.7% was with attention disorders. The year of education, age, age of onset, combination with topiramate significantly related to memory disorders. There is no relevant between year of epilepsy, number of AED and AED generation to domain of memory.

Conclusion: Memory disorders were common in people with epilepsy with polytherapy. Correlated factors are year of education, age, age of onset, combination with topiramate

References

Lê Thụy Minh An (2020). “Động kinh”. Trong: Lê Văn Tuấn. Giáo trình Thần kinh học, 149-175. Nhà xuất bản Đại học Quốc gia Thành phố Hồ Chí Minh, Thành phố Hồ Chí Minh.

Corcoran R., Thompson P. (1992). Memory failure in epilepsy: retrospective reports and prospective recordings. Seizure, 1(1):37-42.

Aldenkamp A. P., Arends J., (2004). Effects of epileptiform EEG discharges on cognitive function: is the concept of “transient cognitive impairment” still valid?. Epilepsy Behav, 5 Suppl 1: 25- 34.

Nguyễn Văn Hướng (2012), Nghiên cứu đặc điểm lâm sàng rối loạn nhận thức và một số yếu tố liên quan trên bệnh nhân động kinh là người trưởng thành, Luận văn Tiến sĩ Y học, Đại học Y Hà Nội.

Phạm Thành Lũy (2018), “Đánh giá chức năng nhận thức ở bệnh nhân động kinh”, Y học Thành phố Hồ Chí Minh, 22(1), tr. 231-237.

Fisher R. S., Acevedo C., Arzimanoglou A., et al. (2014). ILAE official report: a practical clinical definition of epilepsy, Epilepsia, 55(4):475-482.

Helmstaedter C. (2007). Cognitive outcome of status epileptic in adults. Epilepsia, 48(Suppl. 8): 85-90.

Rayner G., Jackson G. D., Wilson S. J. (2016). Mechanisms of memory impairment in epilepsy depend on age at disease onset. Neurology, 87(16):1642- 1649.

Subramaniam S. R., Khoo C. S., Raymond A. A., et al. (2020). Prevalence and factors of verbal learning and memory dysfunction in patients with epilepsy - A single centre study. J Clin Neurosci, 73:31- 36.

Karaaslan Ö., Hamamci M. (2019). Cognitive impairment profile differences in patients with psychogenic non-epileptic seizures and epilepsy patients with generalized seizures. Neurol Res, 42(3):179-188.

Nguyễn Thị Phương Đông (2011), Nghiên cứu một số đặc điểm về trí nhớ trên bệnh nhân động kinh người trưởng thành, Luận văn Tốt nghiệp Bác sĩ Y khoa, Đại học Y Hà Nội.

Fritz N. G S, Hoffmann J., et al., (2005). Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy Behav, 6(3):373-381.