NGHIÊN CỨU GIÁ TRỊ X QUANG CẮT LỚP VI TÍNH TRONG ĐÁNH GIÁ XÂM LẤN CỦA U WILMS Ở TRẺ EM

Tấn Liên Bang Mai; Minh Thương Trương; Thị Ngọc Dung Nguyễn; Minh Vũ Trần; Đức Hải Nguyễn

doi:10.59354/ydth175.2022.37

Keywords:

Computer tomographic, Wilms tumor, children

Abstract

Backgrounds: Wilms’ tumor or nephroblastoma is the most common type of cancer that accounts for 95% of all kidney tumors in children. Imaging diagnosis takes an important role in the detection and diagnosis of tumors and so does Computer tomographic.

Objectives: To determine the value of Computer tomographic in the diagnosis and evaluation of Wilms tumor localization.

Patients and Methods: 62 pediatric patients were diagnosed and operated at the Children Hospital 2 Ho Chi Minh city from 01 June 2013 to 01 June 2017. The patients have had an Computer tomographic study before surgery and had biopsy finding clearly. Study was designed with cases series and cross sectional analysis.

Tools and means of study: CT images were taken by “CT Light Speed” machine with 8 probe ranges of GE incorporation, USA. Results: Computer tomographic could diagnose Wilms tumors with a sensitivity of 86.7%, specificity of 52.9%, positive predictive value of 83%, negative predictive value of 60%, accuracy of 77, 4%. Diagnosis of perirenal involvement with sensitivity: 75.0%, specificity: 73.7%, positive predictive value: 80.8%, negative predictive value: 66.7% body: 74.5%. Signs of invasive lymph nodes: Sensitivity: 66.7%, specificity: 95.5%, positive predictive value: 50%, negative predictive value: 97.7%, accuracy: 93.6 %. Signs of invasive blood vessels: Sensitivity: 60.0%, specificity: 100%, positive predictive value: 100%, negative predictive value: 95.5%, accuracy: 95.7% . Signs of breakage: Sensitivity: 100%, specificity: 97.7%, positive predictive value: 80.0%, negative predictive value: 100%, accuracy: 97.8%. Conclusions: Computer tomographic have been shown to play an important role in invasive assessment: the surrounding organs, lymph nodes, blood vessels, and distant metastases.

References

Trần Đức Hậu (2013). “Nghiên cứu kết quả điều trị u nguyên bào thận theo phác đồ SIOP 2001 tại Bệnh viện Nhi Trung ương”. Tạp chí nhi khoa, tr.54-59.

Ngô Thụy Minh Nhi (2015). Kết quả điều trị bướu Wilms theo phác đồ SIOP 2011, Đại học Y dược Thành Phố Hồ Chí Minh, Luận văn thạc sĩ Y học, 100

Đào Thị Thùy Trang (2013). «Đặc điểm hình ảnh cắt lớp vi tính u nguyên bào thận trẻ em». Tạp chí Y học Thành phố Hồ Chí Minh, 17(1), tr.504.

Al Diab, Hirmas, Almousa, et al. (2017). “Inferior vena cava involvement in children with Wilms tumor”. Pediatric surgery international, 33(5), pp.569-573.

Baldisserotto (2014). “Wilms’ tumor: is computed tomography specific to detect lymph node metastasis?”. Radiologia Brasileira, 47, pp.8-9.

Chiou (2012). “Malignant Renal Tumors in Childhood”. Pediatrics & Neonatology, 55(3), pp.159-160.

Chung, Graeber, Conran (2016). “Renal Tumors of Childhood: Radiologic- Pathologic Correlation Part 1. The 1st Decade: From the Radiologic Pathology Archives”. RadioGraphics, 36(2), pp.499- 522.

Davidoff Andrew M (2012). “Wilms Tumor”. Advances in pediatrics, 59(1), pp.247-267.

Jereb, Tournade, Lemerle, et al. (1980). “Lymph node invasion and prognosis in nephroblastoma”. Cancer, 45(7), pp.1632-1636.

Khanna, Naranjo, Hoffer, et al. (2013). “Detection of Preoperative Wilms Tumor Rupture with CT: A Report from the Children’s Oncology Group”. Radiology, 266(2), pp.610-617.

Kim, Choi, Cho (2014). “Diagnostic value of multidetector computed tomography for renal sinus fat invasion in renal cell carcinoma patients”. Eur J Radiol, 83(6), pp.914.

Miniati, Gay, Parks, et al. (2008). “Imaging accuracy and incidence of Wilms’ and non-Wilms’ renal tumors in children”. J Pediatr Surg, 43(7), pp.1301- 1307.

Oue (2014). “New risk classification is necessary in the treatment of Wilms tumor”. Translational Pediatrics, 3(1), pp.39-41.

Servaes, Khanna, Naranjo, et al. (2015). “Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children’s Oncology Group”. Pediatric radiology, 45(2), pp.166-172.

Silva, Silva (2014). “Local behavior and lymph node metastases of Wilms’ tumor: accuracy of computed tomography”. Radiologia Brasileira, 47, pp.9-13.