THE RELATIONSHIP BETWEEN OSTEOPOROSIS AND DISEASE STAGE, LEVEL OF ACTIVITY AND CORTICOSTEROIDS USING IN RHEUMATOID ARTHRITIS PATIENTS


Authors

  • Lê Hồ Thị Bệnh viện Quân y 175
  • Bình Nguyễn Thanh Bệnh viện Quân y 175
  • Phương Hoàng Thu Bệnh viện Quân y 175
  • Cường Nguyễn Ngọc Bệnh viện Quân y 175
DOI: https://doi.org/10.59354/ydth175.2023.63

Keywords:

Rheumatoid arthritis, osteoporosis, disease stage, corticosteroids

Abstract

Objective: To examine the relationship between osteoporosis and disease stage, level of activity and corticosteroids using in rheumatoid arthritis patients.

Subjects and method: Prospective, cross-sectional study conducted in 65 rheumatoid arthritis patients being treated in military hospital 175. Criteria in reseach: Disease stage according to Steinbroker classification; disease activity according to DAS28, Ritchie, ESR, VAS; osteoporosis according to WHO classification.

Results: The frequence of osteoporosis at measurement were 38,5% at lumbar spine and 41,5% at femoral neck.

Late disease stage (III and IV) increases the odds of osteoporosis at lumbar spine by 13,62 times (p < 0,001; 95%CI: 3,46 – 53,62; at femoral neck by 2,93 times (p < 0,05; 95%CI: 1,03-8,33) compared to early disease stage. Corticosteroids using increases the odds of osteoporosis at lumbar spine by 4,92 times (p < 0,05; 95%CI: 1,01 – 24,29) compared to corticosteroids-naive patients.

Conclussion: In patients with rheumatoid arthritis, late disease stage and corticosteroids using increase the odds of osteoporosis.

References

Kay, J. and K.S. Upchurch, ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology, 2012. 51 (suppl_6): p. vi5-vi9.

Steinbroker, O., C.H. Traeger, and R.C. Batterman, Therapeutic criteria in Rheumatoid Arthritis. Journal of the American Medical Association, 1949. 140(8): p. 659-662.

Lê Anh Thư, Tình trạng loãng xương trên bệnh nhân viêm khớp dạng thấp. Tạp chí Hội Loãng xương TP. Hồ Chí Minh - Đại hội nhiệm kỳ III và Hội nghị khoa học thường niên lần thứ IX, 2015: p. 43.

Trần Thị Hằng., Đánh giá nguy cơ loãng xương ở bệnh nhân viêm khớp dạng thấp bằng chỉ số Amsterdam sửa đổi. 2018, Đại học y Hà Nội.

Heidari, B., et al., Effect of long-term low dose prednisolone administration on bone mineral density: Relating to non-compliant women with rheumatoid arthritis. Caspian Journal of Internal Medicine, 2018. 9(2): p. 171-177.

Lindner, L., et al., Osteoporosis in patients with rheumatoid arthritis: trends in the German National Database 2007– 2017. Rheumatology International, 2020. 40(12): p. 2005-2012.

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Published

27-06-2023

How to Cite

Hồ Thị, L., Nguyễn Thanh, B., Hoàng Thu, P., & Nguyễn Ngọc, C. (2023). THE RELATIONSHIP BETWEEN OSTEOPOROSIS AND DISEASE STAGE, LEVEL OF ACTIVITY AND CORTICOSTEROIDS USING IN RHEUMATOID ARTHRITIS PATIENTS. Journal of 175 Practical Medicine and Pharmacy, (33), 8. https://doi.org/10.59354/ydth175.2023.63

Issue

No. 33 (2023): JOURNAL OF 175 PRACTICAL MEDICINE AND PHARMACY NO 33 - 3/2023

Section

SCIENTIFIC RESEARCH WORKS