NGHIÊN CỨU NỒNG ĐỘ HS-CRP VÀ MỐI LIÊN QUAN VỚI MỘT SỐ YẾU TỐ LÂM SÀNG, CẬN LÂM SÀNG Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TYP 2

Niên Lâm Vĩnh; Thanh Vũ Trí; Anh Nguyễn Lê Hà

doi:10.59354/ydth175.2021.84

Keywords:

hs-CRP, type 2 diabetes

Abstract

Background: Prolonged in inflammation causes vascularcomplications in diabetes. If not controlled and treated promptly, the patient can become disabled and die. Blood hs-CRP test as a useful biomarker of chronic vasculitis, in order to support diagnosis, monitor treatment and detect complications effectively for patients with type 2 diabetes.

Aim: To examine the correlation between blood hs-CRP levels and some biochemical test index (glucose, HbA1c, total cholesterol, LDL-C, HDL-C and triglyceride) in type 2 diabetes patient.

Sample: 238 pepple divided into two groups: group of 118 patients with type 2 diabetes and group of 220 healthy people (control group) having age and gender equivalent to the patient group.

Method: A cross-sectional descriptive study. Patients under clinical examination, history abstraction, intravenous blood werw measured levels of hs-CRP, glucose,HbA1c, total cholesterol, LDL-C, HDL-C and triglyceride. Diagnose type 2 diabetes according to ADA 2020.

Results: Blood hs-CRP (mg/L) in the patient and control groups were 3,9 ± 1,7 compared to 1,7 ± 1,1mg/L (p<0,001). This difference is statistically significant. Patients with high levels of hs-CRP at high and average rick for heart disease were 99.2%. In which, the percentage of patients at high, medium and low levels were72.9; 26.3 and 0.8 respectively. Blood hs-CRP levels were positive correlated with glucose, HbA1c,total cholesterol, LDL-C and triglyceride, inverse correlated with triglyceride Conclusion: The blood hs-CRP levels in type 2 diabetes patients were higher than control group. There is a positive correlation between hs-CRP levels in blood with glucose, HbA1c, total cholesterol, LDL-C and triglyceride, nagative correlated with triglyceride.

References

Nhân Nguyễn Trọng, Thành Vũ Văn (2019). Thực trạng kiến thức và thực hành về chế độ ăn uống của người bệnh đái tháo đường type 2 điều trị ngoại trú tại Bệnh viện Nội tiết tỉnh Bắc Giang năm 2019, Khoa học Điều dưỡng, 2019, tr. 97-104.

Vinh Phạm Nguyễn, Đái Tháo Đường và bệnh Mạch Vành (2012), tầm quan trọng của kiểm soát tích cực LDL-C, Hội nghị khoa học toàn quốc lần VI của hội Nội tiết và Đái tháo đường Việt Nam, 2012, tr. 152.

Aljack HA, High Sensitive C (2019). Reactive Protein in Sudanese Type 2 Diabetic Patients, Sudan Journal of Medical Sciences, 2019, pp. 132-142.

Elimam H et al. (2018), Inflammatory markers and control of type 2 diabetes mellitus, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2018, pp. 800-804.

Kashinakunti SV, Serum High Sensitive - C (2016). Reactive Protein Levels in Type 2 Diabetes Mellitus -A Case Control Study, International Journal of Biochemistry Research & Review, 2016, pp. 1-8.

Roopakala MS (2012), Evaluation of high sensitivity creactive protein and glycated hemoglobin levels in diabetic nephropathy, Saudi Journal of kidney diseases and transplantation, 2012, pp. 286.

Singh M (2020), High-sensitivity C-reactive protein, Malondialdehyde and their association with Glycated hemoglobin (HbA1c) in type 2 diabetes patients, International Journal of Health and Clinical Research, 2020, pp. 81-86.

Singh N (2019), A cross-sectional study on association of high-sensitivity C-reactive proteins (HS-CRP) with dyslipidemia in type 2 diabetic patients of Haryana region, International J. of Healthcare and Biomedical Research, 2019, pp. 30-39.