NGHIÊN CỨU SỰ BIẾN ĐỔI NỒNG ĐỘ THYROGLOBULIN HUYẾT THANH TRÊN BỆNH NHÂN UNG THƯ TUYẾN GIÁP

Hà Nguyễn Thị; Đạt Ngô Quốc; Huy Vũ Quang; Vỹ Trần Thanh; Phúc Nguyễn Hữu; Công Nguyễn Đức

doi:10.59354/ydth175.2021.93

Keywords:

thyroglobulin, thyroid cancer, changes

Abstract

Objective: This study aims to find the relationships between preoperative serum thyroglobulin concentrations and demographic characteristics (age group, gender), thyroid cancer (size of tumor, TNM classification, and type of thyroid cancer) and changes in postoperation.

Methods: A cross-sectional 81 thyroid cancer patients diagnosed by pathology postoperation.

Results: Median preoperative thyroglobulin concentrations was 36.4 ng/mL (17.96 – 69.54) and the rate of high thyroglobulin concentrations was 24.7%. There was no relationships between preoperative serum thyroglobulin concentrations in group <55 years old (39.87 ng/mL) and group ≥55 years old (30.20 ng/mL); male (58.40 ng/ mL) and female (33.89 ng/mL); T1 (34.5 ng/mL) and T2-4 (43.43 ng/mL); N1 (68.87 ng/mL) and N0 (35.45 ng/mL); There is no correlation between histological types of thyroid cancer, serum thyroglobulin concentration, and tumor size with p>0.05. There is a decrease in thyroglobulin concentration in postoperation (3,89 ng/mL) compared to preoperation (51,97 ng/mL) with p=0.0001.

Conclusion: Preoperative serum thyroglobulin concentration is not related to tumor size, TNM stage, metastases, and histological types of thyroid cancer. And there is a decrease in thyroglobulin concentration postoperation compared to preoperation.

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